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The National Cancer Institute Oncology Models Forum (NCI OMF) fills an important need for the diverse cancer research communities who use various genetically engineered, transplantation, induced, and spontaneous mammalian models. The NCI OMF will work with the community to evolve comprehensive information resources to guide generating, validating, and credentialing of new models, informing their practical uses, advancing modeling technologies, software tools, catalogs and other resources. The NCI OMF is also committed to fostering collaborations that ensure effective, dependable translational use of various mammalian species and cell-based models, and open sharing of data that are generated from these models.